Kavli Blog

Videocasts will be available for the open sessions of two upcoming BRAIN Initiative workshops on September 21, 2018 and October 4, 2018.

As mentioned in an earlier announcement, the ACD (Advisory Committee to the NIH Director) BRAIN Initiative Working Group 2.0, co-chaired by Dr. Catherine Dulac (Harvard University) and Dr. John Maunsell (University of Chicago) is holding a series of public, cross-country workshops to solicit input and expert consultations from leaders in the field, as well as to hear from stakeholders in the scientific community and the general public.

The first workshop took place in Boston, Massachusetts, on Friday, August 24th, 2018, broadly addressing human neuroscience through four sessions that were videocast and open to the public. The videocast may be accessed here, and a summary will be available in the coming weeks.

The second workshop, scheduled to take place in Chicago, Illinois, on Friday, September 21st, 2018, will broadly address emerging opportunities, including sensitive molecular and cellular methods to circuit analysis, developing and disseminating new technologies, and revolutionizing circuit-to-behavior analyses. The workshop will include presentations and panel discussions by scientific speakers, broader discussion with the working group, and opportunities for public comment. The videocast may be accessed here. For more information and to register, visit: https://palladianpartners.cvent.com/BRAIN_ACDWG2.

The third workshop, scheduled to take place in Houston, Texas, on Thursday, October 4th, 2018, will broadly address bridging theory and data, through sessions on using theory to build an understanding of brain function, data tools and management, and team versus individual lab science. Like other workshops, there will be presentations and panel discussions by scientific speakers, broader discussion with the working group, and opportunities for public comment. The videocast may be accessed here. For more information and to register, visit: https://palladianpartners.cvent.com/BRAIN_ACDWG3.

For detailed, updated information about these workshops, please visit: https://www.braininitiative.nih.gov/about/acd-wg.htm.

To submit input to the ACD WG at any point, please visit the BRAIN Request for Information (RFI) http://www.braininitiative.nih.gov/rfi.aspxor provide feedback via email to BRAINFeedback@nih.gov. To assure consideration, your responses must be received by November 15, 2018.

NIH announces three re-issued Requests for Applications (RFAs) for team-based interdisciplinary projects using advanced and innovative technologies to examine high-impact questions in human neuroscience and address overarching principles of circuit function as they relate to behavior.

NIH announces three re-issued requests for applications (RFAs) for the BRAIN Initiative. All three RFAs use team-research funding mechanisms (U01 and U19), encouraging diverse and multi-disciplinary teams of researchers to collaborate towards investigation of high-impact human neuroscience and innovative studies of circuit function.

RFA-NS-19-001 Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (U01 Clinical Trial Required)

Invasive surgical procedures allow for precise recording and stimulation within specific brain structures in humans, but the technology is often limited by the number of patients and available resources for conducting complex experimental protocols. Rarely are these resources aggregated in a manner that addresses research questions with appropriate statistical power. Therefore, this RFA seeks applications to assemble diverse, integrated, multi-disciplinary teams that cross boundaries of interdisciplinary collaboration to overcome these fundamental barriers and to investigate high-impact questions in human neuroscience. Projects should maximize opportunities to conduct innovative in vivo neuroscience research made available by direct access to brain recording and stimulating from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and quantitative, mechanistic models where appropriate.

Awardees will join a consortium work group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.

Unlike previous versions, this RFA will support 5 years of a research project. The application receipt date for this RFA is November 14, 2018. Subsequent receipt dates are October 18, 2019, June 19, 2020, and October 19, 2020.

RFA-NS-19-002 Team-Research BRAIN Circuit Programs – TeamBCP (U19 Clinical Trial Required) and RFA-NS-19-003 Team-Research BRAIN Circuit Programs – TeamBCP (U19 Clinical Trial Not Allowed)

This complementary pair of RFAs will support integrated, interdisciplinary research teams that focus on examining circuit functions related to behavior, using advanced and innovative technologies. The goal will be to support programs with a team science approach that can realize meaningful outcomes within 5-plus years. Awards will be made for 5 years, with a possibility of one renewal. Projects will incorporate overarching principles of circuit function in the context of specific neural systems underlying behavior, while also incorporating theory-/model-driven experimental design and offering predictive models as deliverables. Therefore, applications should seek to understand circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating relevant dynamic patterns of neural activity and by measuring the resulting behaviors and/or perceptions. Applications are expected to employ approaches guided by specified theoretical constructs, and are encouraged to employ quantitative, mechanistic models where appropriate. Applications will be required to manage their data and analysis methods in a prototype framework within the proposed U19 project and exchanged with other BRAIN U19 awardees. Model systems, including the possibility of multiple species ranging from invertebrates to humans, can be employed and should be appropriately justified. Programs should employ multi-component teams of research expertise – including neurobiologists, statisticians, physicists, mathematicians, engineers, computer scientists, and data scientists, as appropriate – that cross boundaries of interdisciplinary collaboration.

Based on the new NIH definition of clinical trials, applicants proposing programs that include human subjects with invasive neural recording must apply to RFA-NS-19-002. Applicants proposing programs that do not include human subjects with invasive neural recording must apply to RFA-NS-19-003. The application receipt date for both RFAs is October 30, 2018. Subsequent receipt dates are October 30, 2019 and October 30, 2020.

Please visit our Active Funding Opportunities page for more details on these and other RFAs for the BRAIN Initiative.

Videocasts will be available for the open sessions of two upcoming BRAIN Initiative workshops on August 24 and September 21, 2018.

As mentioned earlier, the ACD (Advisory Committee to the NIH Director) BRAIN Initiative Working Group 2.0, co-chaired by Dr. Catherine Dulac (Harvard University) and Dr. John Maunsell (University of Chicago) is holding a series of public, cross-country workshops to solicit input and expert consultations from leaders in the field, as well as to hear from stakeholders in the scientific community and the general public.

The first workshop, scheduled to take place in Boston, Massachusetts, on Friday, August 24th, 2018, will broadly address human neuroscience through four sessions that will be videocast and open to the public. The workshop will include presentations and panel discussions by scientific speakers, broader discussion with the working group, and opportunities for public comment. The videocast may be accessed here. Due to a high volume of local community interest in this workshop, the venue for the general session has been changed. For more information and to register, visit: https://palladianpartners.cvent.com/BRAIN_ACDWG1.

The second workshop, scheduled to take place in Chicago, Illinois, on Friday, September 21st, 2018, will broadly address emerging opportunities, including sensitive molecular and cellular methods to circuit analysis, developing and disseminating new technologies, and revolutionizing circuit-to-behavior analyses. As with the first event, this workshop will include presentations and panel discussions by scientific speakers, broader discussion with the working group, and opportunities for public comment. The videocast may be accessed here. For more information and to register, visit: https://palladianpartners.cvent.com/BRAIN_ACDWG2.

For detailed, updated information about these workshops, please visit: https://www.braininitiative.nih.gov/about/acd-wg.htm.

And, to submit input to the ACD WG at any point, please visit the BRAIN Request for Information (RFI) at www.braininitiative.nih.gov/rfi.aspx or provide feedback via email to BRAINFeedback@nih.gov. To assure consideration, your responses must be received by November 15, 2018.

Videocasts will be available for the open sessions of three upcoming BRAIN Initiative events on August 13, August 14, and August 24, 2018.

The NIH BRAIN Initiative Multi-Council Working Group (MCWG), consisting of non-Federal representatives from various NIH Institutes and Centers participating in BRAIN, at-large members, and ex officio representatives from DARPA, FDA, IARPA and NSF, provides ongoing oversight of the long-term scientific vision of the NIH BRAIN Initiative, in the context of the evolving neuroscience landscape. The eleventh meeting of the MCWG will occur on Tuesday, August 14th, 2018, at the NIH Porter Neuroscience Research Center (35 Convent Dr., Bethesda, MD 20892). The videocast may be accessed here.

The Neuroethics Working Group of the MCWG recommends overall approaches for how the NIH BRAIN Initiative might handle issues and problems involving ethics. The sixth meeting of the Neuroethics Working Group will occur on Monday, August 13th, 2018, at the NIH Porter Neuroscience Research Center (35 Convent Dr., Bethesda, MD 20892). The videocast may be accessed here.

The ACD (Advisory Committee to the NIH Director) BRAIN Initiative Working Group 2.0, co-chaired by Dr. Catherine Dulac (Harvard University) and Dr. John Maunsell (University of Chicago) is holding a series of public, cross-country workshops to solicit input and expert consultations from leaders in the field, as well as to hear from stakeholders in the scientific community and the general public. The first workshop, scheduled to take place in Boston, Massachusetts, on Friday, August 24th, 2018, will broadly address human neuroscience through four sessions that will be videocast and open to the public. The workshop will include presentations and panel discussions by scientific speakers, broader discussion with the working group, and opportunities for public comment. The videocast may be accessed here.

NIH BRAIN Initiative seeks input through a Request for Information (RFI) from key stakeholders on how to best accomplish the ambitious scientific vision of the BRAIN 2025 report.

NIH is happy to solicit input on how best to accomplish the ambitious vision for the BRAIN Initiative from all interested stakeholders, including members of the scientific community, trainees, academic institutions, the private sector, health professionals, professional societies, advocacy groups, and patient communities, as well as other interested members of the public.

BRAIN 2025: A Scientific Vision serves as the strategic plan for the BRAIN Initiative at NIH and outlines an overarching vision, seven high level scientific priorities, and many specific goals. As the Initiative approaches its midpoint, NIH seeks feedback on the BRAIN Initiative’s progress and on opportunities moving forward, given the current state of the science.

NIH has established a new BRAIN Initiative Advisory Committee of the NIH Director (ACD) Working Group (WG) who will provide scientific guidance to the ACD on how best to continue to accelerate the ambitious vision for the BRAIN Initiative. The ACD-WG will use the responses to this RFI, along with information gathered through a series of public workshops, to help inform their discussions of the BRAIN Initiative’s progress and potential updates to the plan moving forward. The first workshop takes place on August 24, 2018, in Boston – for more information and to register, visit: https://palladianpartners.cvent.com/BRAIN_ACDWG1.

Please submit ideas and suggestions for new tools and technologies, and/or questions about brain circuit function that could be addressed with novel neurotechnologies. The NIH would also like your input on considerations and approaches on dissemination and training, data sharing infrastructure and policies, ethical implications of BRAIN Initiative-supported research advancements, as well as any other topic relevant to the strategic plan of the BRAIN Initiative.

To assure consideration, your responses must be received by November 15, 2018. Responses to this RFI must be submitted electronically using the web-based form (www.braininitiative.nih.gov/rfi.aspx) or via email to BRAINFeedback@nih.gov.